Abstract 2501 Manganese superoxide dismutase hyper-acetylation in breast cancer

Manganese superoxide dismutase (MnSOD) reduces superoxide from the electron transport chain into hydrogen peroxide in the mitochondria. MnSOD is also known to play a role in tumor growth and invasiveness in breast cancers; however, most studies focus on expression levels of MnSOD not necessarily activity. Lysine 68 is an enzymatically important amino acid that can be reversibly acetylated, significantly reducing dismutase activity. In this study CRISPR knock-in MnSODK68Q MCF7 cells were used to mimic hyper-acetylation of lysine 68.