Abstract 1628 xCT Protein Expression in Epstein-Barr Virus Infected Cells

The Epstein-Barr virus (EBV), one of the most common viruses in the world, is a member of the herpesvirus family and causes infectious mononucleosis and various cancers. EBV is found in its latent, inactive cycle, in Burkitt lymphoma and other cancers. Upon reactivation into its lytic, active cycle, EBV has increased horizontal spread to other cells. The host genes and proteins related to EBV reactivation are of great interest, as they can dictate whether the virus is able to reactivate. When known inhibitors of EBV reactivation, valpromide (VPM) and valproic acid (VPA), are added to EBV-infected cancer cells, human host cell gene SLC7A11 expression increases.