Abstract 1105 Adipose stem cells from the human omentum secrete exosomes to promote healing by regulating apoptosis and immune response pathways in vivo
The omental adipose depot, a visceral adipose tissue, surrounds lower abdomen organs such as the colon, small intestine, spleen, bladder, and reproductive organs. The omentum is known to respond to internal injuries and infections by walling off injuries and by absorbing bacteria and other foreign material. Further, it has been documented that the omentum moves about peritoneal cavity to aid in its response to injuries and infections. Due to its functions in combating internal injuries, we aimed to understand the molecular mechanisms that were associated with the exosomes released from the omental adipose stem cells (om-hASCexo).
Authors
- Niketa Patel (ORCID: https://orcid.org/0000-0003-4811-8596)
- Brenna Osborne (ORCID: https://orcid.org/0000-0002-0197-3010)
- Bangmei Wang
- Paul Albear
- Meredith Krause‐Hauch (ORCID: https://orcid.org/0000-0002-4591-9286)
- Rekha Patel (ORCID: https://orcid.org/0009-0002-7329-4516)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.108790
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Eye Institute