Abstract 1728 Pharmacological stabilization of G-quadruplex structures increases RYBP transcription in glioblastoma cells

Glioblastoma multiforme (GBM) is the most common and lethal central nervous system cancer. GBM tumors frequently display aberrant levels of Polycomb (Pc) proteins, which mediate normal cell differentiation and identity, contributing to gene dysregulation that drives GBM progression. The Pc protein RING1- and YY1-binding protein (RYBP) is a transcription factor and a chromatin-modifying protein that exerts tumor suppressive effects in many cancers. While GBM tumors frequently downregulate RYBP in comparison to normal brain tissue, the mechanism of RYBP silencing in GBM remains unreported.