Abstract 2030 PLK1 promotes prostate cancer by activating STAT6 signaling and elevating M2-subtype macrophages

Purpose: PLK1 has been postulated to have a pro-tumorigenesis function. Integrating our recently generated prostate-specific PLK1 knock-in genetically engineered mouse model (GEM) and the transcriptome data of human prostate cancer (PCa) patients, we aimed to establish an oncogenic role for PLK1 in PCa progression. To elucidate the underlying mechanism, we investigated the relationship between PLK1 and the tumor microenvironment (TME). Experimental Design: After the mRNA expression of PLK1 was identified in human PCa from the TCGA database, PLK1 protein expression was scored by clinical pathologists utilizing immunohistochemistry in a clinical cohort via a tissue microarray (TMA).