Abstract 2131 H. pylori upregulates PD-L1 expression for immune evasion via mTOR ubiquitination and activation

Helicobacter pylori (H. pylori) is a human pathogen that colonizes the stomach of more than half of the population. The infected host is unable to clear the bacteria even with the induction of innate and adaptive immune responses. Persistent H. pylori infection is the leading cause of chronic gastritis, peptic ulcer disease and gastric cancer. Virulence factors of H. pylori play an important role in the pathogenicity of H. pylori infection. The cytotoxin-associated gene A (CagA) protein of H. pylori is delivered into the host gastric epithelial cells by bacterial type IV secretion system (T4SS) and hijacks host signaling molecules to promotes neoplastic transformation of gastric epithelial cells.