Abstract 1261 Development of biotechnology to study interindividual variability in human drug metabolism

Human carboxylesterases (CESs) are hydrolases found in the digestive tract and liver responsible for the metabolism of many ester-containing medications including antiviral medications as Oseltamivir, used in the treatment for the flu, and Redemsivir, a treatment for COVID-19. Clinical and ex vivo studies have demonstrated that CES activity can vary person to person due to a variety of factors. One such factor of particular interest are nonsynonymous single nucleotide polymorphisms (nsSNPs) which causes sequence changes in the CES protein.