Abstract 1030 Chemical Tools for Biological Discoveries

In the Raj lab, we develop novel chemical probes and sensors for global profiling of undruggable proteome, selective detection of posttranslational modifications (PTMs), and biological metabolites. This research program leads to the discovery of novel protein biomarkers, affordable diagnostic tools for the early detection of cancer, and endogenous protein partners thus facilitating the synthesis of biotherapeutics. In my talk, I'll focus on our efforts towards the identification of proteins and PTMs at a single molecule level in a cell or an organism to understand biological processes, disease analysis and biomarker discovery.