Abstract 2798 Functional impact of CXCR4 oligomerization on signal transduction and drug resistance

The chemokine receptor CXCR4, a G-protein coupled receptor (GPCR), plays a pivotal role in immune cell migration and is implicated in diseases such as cancer, inflammation, and immune disorders. We discovered CXCR4 oligomerization has emerged as a critical determinant of receptor signaling, enhancing G-protein activity while reducing β-arrestin-mediated internalization. These changes are likely to contribute to functional selectivity, drug resistance, and reduced efficacy of FDA-approved CXCR4 inhibitors.