Abstract 1698 Actin Regulation at Endosomes: Mechanisms Orchestrating the Early and Late Stages Of Endosome Fission

Fission at endosomes is required to release cargo-laden carrier vesicles so that they can be recycled back to the plasma membrane. Actin branching plays a crucial role in the early stages of endosome fission by constricting the neck of the budding vesicle and facilitating enzyme-mediated fission. However, our understanding of how the early constriction stage and later enzyme-based stage of endosome fission are coordinated is limited, especially regarding the mechanisms of actin regulation throughout the process.