Abstract 2729 13C-Labeled Probes for Ovarian Cancer Screening via Beta-Galactosidase Detection

Ovarian cancer remains one of the deadliest cancers, with only 20% of cases detected early. Early detection drastically improves survival rates, with over 94% of patients surviving more than five years when the disease is identified at an early stage. However, no reliable screening methods currently exist. Commonly used tools, such as transvaginal ultrasound (TVUS) and the CA-125 blood test, have significant limitations. TVUS can detect masses but cannot distinguish between benign and malignant growths, while the CA-125 test lacks specificity, as elevated levels are often caused by non-cancerous conditions like endometriosis.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.108942
Primary Topic
Cancer Research and Treatments
Type
article
Field-Weighted Citation Impact
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article

Abstract 2729 13C-Labeled Probes for Ovarian Cancer Screening via Beta-Galactosidase Detection

Stephen Dye, J. K. C. Chan
Journal of Biological Chemistry
Cancer Research and Treatments
article

Abstract 2729 13C-Labeled Probes for Ovarian Cancer Screening via Beta-Galactosidase Detection

Stephen Dye, J. K. C. Chan
article en

Abstract

Ovarian cancer remains one of the deadliest cancers, with only 20% of cases detected early. Early detection drastically improves survival rates, with over 94% of patients surviving more than five years when the disease is identified at an early stage. However, no reliable screening methods currently exist. Commonly used tools, such as transvaginal ultrasound (TVUS) and the CA-125 blood test, have significant limitations. TVUS can detect masses but cannot distinguish between benign and malignant growths, while the CA-125 test lacks specificity, as elevated levels are often caused by non-cancerous conditions like endometriosis.

Journal of Biological ChemistryVol. 301(5)
Western Michigan University (US)
Zero hunger
Openalex Percentile: Top 85%
Cancer Research and Treatments
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