Abstract 1919 New Approaches to Target Undruggable Proteins
Dr. Jian Jin's lab is a leader in discovering novel small-molecule degraders for oncoproteins and developing new technologies for advancing the targeted protein degradation (TPD), targeted protein stabilization (TPS) and targeted protein acetylation (TPA) field. In particular, we have developed innovative approaches such as Bridged PROTAC, TF-PROTAC, TF-DUBTAC and AceTAC to target undruggable proteins. Our recent progress in this research area will be presented.
Authors
- Jian Jun Jin (ORCID: https://orcid.org/0000-0002-2387-3862)
Institutions
- Mount Sinai Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.108917
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- University of Texas at Arlington