Abstract 3043 Chemical Biology Approaches Reveal Epigenetic Control of Chromatin States in Health and Disease

The epigenetic regulation of DNA-templated processes is intricately tied to numerous events that determine cell phenotype and fate. The abrogation of epigenetic cascades drives various disease states, including cancer. In my talk, I will describe how we utilize chemical biology to investigate the fundamental principles of chromatin and epigenetic regulation, with the goal of uncovering novel therapeutic strategies. By dissecting chromatin dynamics and transcriptional control in both normal and disease contexts, we aim to understand how these processes govern cell fate and dysfunction.