Abstract 2153 Dephosphorylation of nucleoporins by calcineurin regulates nuclear import and export rates

Calcineurin is a ubiquitously expressed, Ca2+/calmodulin-regulated protein phosphatase that is essential for many cellular processes, including T-cell activation. The catalytic role of this protein is effectively inhibited by the immunosuppressants cyclosporin A and tacrolimus (FK506). However, these drugs cause a myriad of adverse and unexplained effects in non-immune cells, where the targets of calcineurin remain largely unidentified. Recently, Wigington et al. (2020) showed that multiple nuclear pore proteins (Nups), including Nup153 and TPR, served as calcineurin substrates in both in vivo and in vitro environments.