Abstract 2059 An Investigation into the OxyR A105V Mutant in Caulobacter crescentus

The Lon protease is an important ATP-dependent protease for protein quality control and helps to maintain cellular homeostasis when the cell is under stress. Deletion of lon in Caulobacter crescentus results in growth defects under oxidative stress, but how the Lon protease is involved in this response remains unclear. In a screen for suppressors of this phenotype we identified a gain-of-function allele of the oxidative stress response regulator OxyR. In this work, we characterize this mutation to understand the mechanism of this suppression.