Abstract 2787 The Multifaceted Role of Arid5a in EMT, Tumor Invasion, and Immune Suppression in Pancreatic Cancer

The epithelial-mesenchymal transition (EMT) is a critical process in cancer progression, driving malignant phenotypes such as invasiveness, metastatic potential, drug resistance, and immune suppression. Chronic inflammation mediated by pro-inflammatory cytokines, including IL-6, has been shown to contribute to cancer malignancy by promoting these aggressive phenotypes. Recent studies have identified AT-rich interaction domain-containing protein 5a (Arid5a), an RNA-binding protein, as a stabilizer of IL-6 mRNA, enhancing its production and contributing to an inflammatory microenvironment that promotes EMT.