Abstract 2417 Serine starvation inhibits SRSF protein expression and modulates RNA splicing

Breast cancer is the most common cancer in women worldwide, and luminal/estrogen receptor positive (ER+) breast cancer accounts for ∼50% of breast cancer deaths. Our lab has identified serine auxotrophy as a metabolic vulnerability of luminal/ER+ breast tumors due to low levels of the serine synthesis enzyme phosphoserine aminotransferase 1 (PSAT1). Serine is critically important for cancer cell growth due to its multiple downstream functions in protein, nucleotide, and lipid biosynthesis. There is considerable interest in starving serine auxotrophic tumors of serine for therapy, including an ongoing clinical trial in pancreatic cancer.