Abstract 2747 Molecular mechanisms of epigenetic regulation

Epigenetic marks regulate chromatin structure and function, alter local chromatin environment, affect DNA accessibility and accelerate or impede DNA templated processes. Histone posttranslational modifications (PTMs) alter direct interactions between histones and DNA and serve as docking sites for the histone-binding domains or “readers”. Here, I will detail the molecular mechanisms and biological roles of the readers found in MOZ, p300 and MLL complexes. I will compare specificities and discuss the significance of crosstalk between PTMs and the consequence of combinatorial readout for the recruitment of these complexes to chromatin.