Abstract 2237 Developing Chemogenetic Fluorescent Biosensors for Extracellular ATP

Adenosine 5'-triphosphate (ATP) functions as a universal energy currency within living organisms among other important functions such as mediating purinergic signaling. Its ubiquitous presence as an extracellular signaling molecule in diverse cell to cell communications makes it a key indicator of different cellular activities and metabolic functions. Thus, motivating ATP as a promising target for more advanced fluorescent biosensor development. Our broad goal is to develop more reliable and accurate optical tools to target and detect extracellular ATP.