Abstract 1394 Cannabidiol enhances lipid droplet deposition along with the expression of FABP4 and AGPAT in 3T3-L1 preadipocytes

Cannabidiol (CBD), a non-psychoactive compound from the Cannabis sativa plant, has emerged as a potential therapeutic agent due to its regulatory effects on various metabolic processes. This study explored the influence of CBD on adipocyte differentiation by examining its effects on two key differentiation markers: Fatty Acid Binding Protein 4 (FABP4) and 1-Acylglycerol-3-Phosphate Acyltransferase (AGPAT). FABP4 is integral to fatty acid transport and lipid storage within adipocytes, while AGPAT plays a pivotal role in phospholipid and triglyceride biosynthesis, essential for lipid accumulation.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.108799
Primary Topic
Lipid metabolism and biosynthesis
Type
article
Field-Weighted Citation Impact
0.00
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article

Abstract 1394 Cannabidiol enhances lipid droplet deposition along with the expression of FABP4 and AGPAT in 3T3-L1 preadipocytes

Nickawn Namdar
Journal of Biological Chemistry
Lipid metabolism and biosynthesis
article

Abstract 1394 Cannabidiol enhances lipid droplet deposition along with the expression of FABP4 and AGPAT in 3T3-L1 preadipocytes

Nickawn Namdar
article en

Abstract

Cannabidiol (CBD), a non-psychoactive compound from the Cannabis sativa plant, has emerged as a potential therapeutic agent due to its regulatory effects on various metabolic processes. This study explored the influence of CBD on adipocyte differentiation by examining its effects on two key differentiation markers: Fatty Acid Binding Protein 4 (FABP4) and 1-Acylglycerol-3-Phosphate Acyltransferase (AGPAT). FABP4 is integral to fatty acid transport and lipid storage within adipocytes, while AGPAT plays a pivotal role in phospholipid and triglyceride biosynthesis, essential for lipid accumulation.

Journal of Biological ChemistryVol. 301(5)
Denison University (US)
Zero hunger
Openalex Percentile: Top 86%
Lipid metabolism and biosynthesis
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