Abstract 2054 Developing a Pipeline to Identify Novel Type IV Secretion System Inhibitors for Combating Antimicrobial Resistance

Antimicrobial resistance (AMR) is a major global threat, causing an estimated 700,000 deaths per year. One of the main ways that AMR genes spread among bacteria is through conjugation. Therefore, it is crucial to develop conjugation inhibitors (COINs) to combat AMR. Shared characteristics between known COIN molecules are a hydrophobic tail, unsaturations, and a polar head. Following these characteristics and accounting for the efficacy of 2-hexadecynoic acid and tanzawaic acids (TZAs) low toxicity, we designed a new set of TZA analogs.