Abstract 1668 Age-related change of interaction between endothelial cells and neutrophils in muscle tissue during wound healing

Objective: Delayed healing of skeletal muscle injuries associated with aging is a serious matter because it leads to a reduction in healthy lifespan. It has been reported that age-related disturbances in the immune system affect this phenomenon. However, it is still unclear how the immune system response to vascular remodeling after muscle injury changes with age. The aim of this study is to clarify the age-related changes of interaction between the immune system and endothelial cells in vascular remodeling after muscle injury.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.108972
Primary Topic
Diabetic Foot Ulcer Assessment and Management
Type
article
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article

Abstract 1668 Age-related change of interaction between endothelial cells and neutrophils in muscle tissue during wound healing

Yuri Yamashita, Taro Kunitomi, Eri Arikawa‐Hirasawa
Journal of Biological Chemistry
Diabetic Foot Ulcer Assessment and Management
article

Abstract 1668 Age-related change of interaction between endothelial cells and neutrophils in muscle tissue during wound healing

Yuri Yamashita, Taro Kunitomi, Eri Arikawa‐Hirasawa
article en

Abstract

Objective: Delayed healing of skeletal muscle injuries associated with aging is a serious matter because it leads to a reduction in healthy lifespan. It has been reported that age-related disturbances in the immune system affect this phenomenon. However, it is still unclear how the immune system response to vascular remodeling after muscle injury changes with age. The aim of this study is to clarify the age-related changes of interaction between the immune system and endothelial cells in vascular remodeling after muscle injury.

Journal of Biological ChemistryVol. 301(5)
Juntendo University (JP)
Zero hunger
Openalex Percentile: Top 81%
Diabetic Foot Ulcer Assessment and Management
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