Abstract 1580 Identifying the Synaptic Pairing-Partners of an NF-κB that Modulate Alcohol Sensitivity

Animations are effective media that enable researchers to explore, communicate, and gain new insights into complex biological processes.However, the technical complexity and steep learning curve of traditional 3D animation software have hindered their widespread adoption in scientific research.This project addresses these challenges by developing accessible software tools that empower researchers to create their own molecular models and animations.Leveraging the open-source animation software Blender, we are building a suite of tools specifically tailored for molecular animations.These tools will allow users to import Protein Data Bank (PDB) and AlphaFold structural models directly into Blender and build customized molecular representations.Researchers will be able to define conformational states of molecular complexes and generate animated trajectories that transition between these states.Additionally, the tools will support the creation of simplified animations to visualize molecular interactions and movements, offering an intuitive means of depicting complex biological processes.All tools will be implemented as free Blender addons, using Python scripting and Blender's Geometry Nodes procedural system.To enhance accessibility and promote collaboration within the scientific community, we are also developing platforms for archiving, annotating, and sharing animated molecular models.These platforms will enable broader dissemination and use of molecular animations in research and science communication.