Abstract 2827 In silico analysis of gliadin-transglutaminase interactions in celiac disease

Celiac disease is an incurable autoimmune condition attributed to consumption of gluten and consequent degradation of epithelial cells in small intestine. The pathogenesis of celiac disease is relatively well understood, with autoimmune response largely depending on transglutaminase-2(TG2). TG2 is a multifaceted enzyme responsible for various functions, from its function as transglutaminase to nonenzymatic activities. This study serves as an in silico conformation of results from literature and begins to explore the link between dynamics of TG2 and celiac disease.