Abstract 1479 Interactions of Corticosteroid Drugs with Human Gut Microbiome-Derived Dehydrogenases

The proteins found in gut microbiota are capable of metabolizing not only the food that we consume, but also commonly prescribed pharmaceuticals. These pharmaceuticals can be transformed to activate and deactivate drugs, or create toxic metabolites. The specific reactions that take place are widely undocumented, indicating a need to identify potential drug interactions and their products. This study focuses on metabolic enzymes such as “desmolase” enzymes and 17-hydroxysteroid dehydrogenases (HSDHs), which are known to modify corticosteroids to produce androgenic compounds, and other HSDHs known to modify unique positions around the steroid core.