Bioactive Rosane and Podocarpane Diterpenoids From the Whole Plant of <i>Jatropha curcas</i> L.
One previously undescribed rosane diterpenoid (1) and 13 known ones (2-14) were isolated from the whole plant of Jatropha curcas L. The relative configuration 1 was determined by NMR calculation combined with DP4+ probability analysis, and its absolute configuration (AC) was further determined by ECD calculation. The final structure was further confirmed by single crystal x-ray diffraction. The biological testing revealed that compounds 5 and 14 possessed inhibitory effects on NLRP3 inflammasome with IC<sub>50</sub> values of 8.1 ± 0.3 and 9.7 ± 0.4 µM. Further investigation exhibited that compound 5 has an obvious effect on inhibiting pyroptosis.
Authors
- Chao‐Jun Li (ORCID: https://orcid.org/0000-0002-3859-8824)
- Xue Wu (ORCID: https://orcid.org/0000-0002-2607-8717)
- Yanling Tang (ORCID: https://orcid.org/0000-0002-5256-919X)
- Yanfang Li (ORCID: https://orcid.org/0000-0002-9675-4864)
- Muhammad Aurang Zeb (ORCID: https://orcid.org/0000-0001-5841-3500)
- Wei‐Lie Xiao (ORCID: https://orcid.org/0000-0001-6826-1993)
- Xing‐Jie Zhang (ORCID: https://orcid.org/0000-0003-1163-3703)
- Bo Li (ORCID: https://orcid.org/0000-0002-7337-0112)
- Xiaoli Li (ORCID: https://orcid.org/0000-0002-5590-3632)
- Zhong‐Dan Liang
- Qi Li (ORCID: https://orcid.org/0000-0002-9429-1368)
Institutions
- Yunnan University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1002/cbdv.202500956
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81