Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention

Our integrative proteogenomic and observational analyses suggest a potential protective role of lower circulating ANGPTL4 concentrations in colorectal cancer risk. These findings support further evaluation of ANGPTL4 as a therapeutic target for colorectal cancer prevention.

Authors

Institutions

Publication Details

Journal
JNCI Journal of the National Cancer Institute
Published
2025-06-06
DOI
https://doi.org/10.1093/jnci/djaf137
Citations
3
Primary Topic
Lipid metabolism and disorders
Type
article
Field-Weighted Citation Impact
4.16

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention

James Yarmolinsky, Konstantinos K. Tsilidis, Evelyn Lau, Alexander Smith et al.
3 citations
JNCI Journal of the National Cancer Institute
Lipid metabolism and disorders
4.16
article

Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention

James Yarmolinsky, Konstantinos K. Tsilidis, Evelyn Lau, Alexander Smith, Ioanna Tzoulaki, Ferrán Moratalla-Navarro, Matthew A. Lee, Patrick C.N. Rensen, Dennis Wang, Shama Virani, Michael O. Woods, Vı́ctor Moreno, Loı̈c Le Marchand, Sabina Sieri, Tom Dudding, Giovanna Masala, Fränzel J.B. van Duijnhoven, Marcela Guevara, Ruifang Li‐Gao, Marc J. Gunter, Jochen Hampe, Ko Willems van Dijk, Abbas Dehghan, Emma E. Vincent, Apiwat Sangphukieo, Kala Visvanathan, Keren Papier, Elmira Ebrahimi
article en
3 citations

Abstract

Our integrative proteogenomic and observational analyses suggest a potential protective role of lower circulating ANGPTL4 concentrations in colorectal cancer risk. These findings support further evaluation of ANGPTL4 as a therapeutic target for colorectal cancer prevention.

JNCI Journal of the National Cancer InstituteVol. 117(9)
Agency for Science, Technology and Research (SG), University of Hawaiʻi at Mānoa (US), Memorial University of Newfoundland (CA), University of Hawaii System (US), Johns Hopkins University (US), University of Ioannina (GR), Academy of Athens (GR), Leiden University Medical Center (NL), University Of Bristol Dental Hospital (GB), Prevention Institute (US), University of Bristol (GB), University of Oxford (GB), Instituto de Salud Pública de Navarra (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Biomedical Research Foundation of the Academy of Athens (GR), Cancer Center of Hawaii (US), Lung Institute (US), Ajuntament de L’Hospitalet (ES), Institut Català d'Oncologia (ES), Navarre Institute of Health Research (ES), UK Dementia Research Institute (GB), Mylan (Switzerland) (CH), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Fondazione IRCCS Istituto Nazionale dei Tumori (IT), MRC Epidemiology Unit (GB), Centre international de recherche sur le cancer (FR), MRC Integrative Epidemiology Unit, University of Hawaii Cancer Center, Imperial College London (GB), Universitat de Barcelona (ES), Technische Universität Dresden (DE), Wageningen University & Research (NL)
Centres de Recerca de Catalunya, National Institute for Health and Care Research, Generalitat de Catalunya, Engineering and Physical Sciences Research Council, Instituto de Salud Carlos III, Rijksinstituut voor Volksgezondheid en Milieu, NIHR Imperial Biomedical Research Centre
Openalex Percentile: Top 6%
Lipid metabolism and disorders
4.16
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.