Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention
Our integrative proteogenomic and observational analyses suggest a potential protective role of lower circulating ANGPTL4 concentrations in colorectal cancer risk. These findings support further evaluation of ANGPTL4 as a therapeutic target for colorectal cancer prevention.
Authors
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Konstantinos K. Tsilidis (ORCID: https://orcid.org/0000-0002-8452-8472)
- Evelyn Lau (ORCID: https://orcid.org/0000-0003-3281-8360)
- Alexander Smith (ORCID: https://orcid.org/0000-0001-6418-613X)
- Ioanna Tzoulaki (ORCID: https://orcid.org/0000-0002-4275-9328)
- Ferrán Moratalla-Navarro (ORCID: https://orcid.org/0000-0001-7858-5713)
- Matthew A. Lee (ORCID: https://orcid.org/0000-0001-6262-3447)
- Patrick C.N. Rensen (ORCID: https://orcid.org/0000-0002-8455-4988)
- Dennis Wang (ORCID: https://orcid.org/0000-0003-0068-1005)
- Shama Virani (ORCID: https://orcid.org/0000-0002-1163-432X)
- Michael O. Woods (ORCID: https://orcid.org/0000-0001-8180-418X)
- Vı́ctor Moreno (ORCID: https://orcid.org/0000-0002-2818-5487)
- Loı̈c Le Marchand (ORCID: https://orcid.org/0000-0001-5013-980X)
- Sabina Sieri (ORCID: https://orcid.org/0000-0001-5201-172X)
- Tom Dudding (ORCID: https://orcid.org/0000-0003-3756-040X)
- Giovanna Masala (ORCID: https://orcid.org/0000-0002-5758-9069)
- Fränzel J.B. van Duijnhoven (ORCID: https://orcid.org/0000-0001-8367-2352)
- Marcela Guevara (ORCID: https://orcid.org/0000-0001-9242-6364)
- Ruifang Li‐Gao (ORCID: https://orcid.org/0000-0003-0650-1351)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Jochen Hampe (ORCID: https://orcid.org/0000-0002-2421-6127)
- Ko Willems van Dijk (ORCID: https://orcid.org/0000-0002-2172-7394)
- Abbas Dehghan (ORCID: https://orcid.org/0000-0001-6403-016X)
- Emma E. Vincent (ORCID: https://orcid.org/0000-0002-8917-7384)
- Apiwat Sangphukieo (ORCID: https://orcid.org/0000-0001-5210-5398)
- Kala Visvanathan (ORCID: https://orcid.org/0000-0002-0582-8005)
- Keren Papier (ORCID: https://orcid.org/0000-0002-4102-6835)
- Elmira Ebrahimi (ORCID: https://orcid.org/0000-0003-0910-3447)
Institutions
- Agency for Science, Technology and Research (SG)
- University of Hawaiʻi at Mānoa (US)
- Memorial University of Newfoundland (CA)
- University of Hawaii System (US)
- Johns Hopkins University (US)
- University of Ioannina (GR)
- Academy of Athens (GR)
- Leiden University Medical Center (NL)
- University Of Bristol Dental Hospital (GB)
- Prevention Institute (US)
- University of Bristol (GB)
- University of Oxford (GB)
- Instituto de Salud Pública de Navarra (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Cancer Center of Hawaii (US)
- Lung Institute (US)
- Ajuntament de L’Hospitalet (ES)
- Institut Català d'Oncologia (ES)
- Navarre Institute of Health Research (ES)
- UK Dementia Research Institute (GB)
- Mylan (Switzerland) (CH)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- MRC Epidemiology Unit (GB)
- Centre international de recherche sur le cancer (FR)
- MRC Integrative Epidemiology Unit
- University of Hawaii Cancer Center
- Imperial College London (GB)
- Universitat de Barcelona (ES)
- Technische Universität Dresden (DE)
- Wageningen University & Research (NL)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1093/jnci/djaf137
- Citations
- 3
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Centres de Recerca de Catalunya
- National Institute for Health and Care Research
- Generalitat de Catalunya
- Engineering and Physical Sciences Research Council
- Instituto de Salud Carlos III
- Rijksinstituut voor Volksgezondheid en Milieu
- NIHR Imperial Biomedical Research Centre