Effect of recombinant human parathyroid hormone and zoledronic acid on osteoblast gene expression using multifaceted approach: An in vitro study
We conclude that rhPTH (5 μg) treatment followed by ZOL (1 μM) showed the best anabolic or bone-forming effect. Our results warrant further research in assessing similar combinations of anti-fracture drugs, which augment osteogenesis to maximize their anabolic effects in preventing osteoporosis in susceptible individuals.
Authors
- Sanjay Kumar Bhadada (ORCID: https://orcid.org/0000-0002-0410-8778)
- Gurpal Singh (ORCID: https://orcid.org/0000-0003-1665-145X)
- D. K. Dhawan (ORCID: https://orcid.org/0000-0003-3399-6732)
- Anil Bhansali
- Swati Bhat
- Vandana Dhiman (ORCID: https://orcid.org/0000-0001-9304-5600)
- Ravi Pratap Barnwal (ORCID: https://orcid.org/0000-0003-3156-5357)
- Amanjit Bal (ORCID: https://orcid.org/0000-0002-1457-8589)
- Sudhaker D. Rao (ORCID: https://orcid.org/0000-0002-2200-1800)
- Naresh Kumar Sachdeva (ORCID: https://orcid.org/0000-0001-6289-4749)
- Gurjeet Kaur (ORCID: https://orcid.org/0000-0003-3322-5030)
- Poonam Kanta
Institutions
- Henry Ford Health System (US)
- Post Graduate Institute of Medical Education and Research (IN)
- Panjab University (IN)
Publication Details
- Journal
- Indian Journal of Pharmacology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.4103/ijp.ijp_582_23
- Citations
- 2
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09