The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment
Eighty adults ≥ 60 years with mild cognitive impairment entered a placebo-controlled randomized controlled trial evaluating lithium's neuroprotective properties.Participants were followed for 2 years with baseline and follow-up evaluations at 1 and 2 years that included neurocognitive assessment, ultra-high-field structural neuroimaging, positron emission tomography imaging for amyloid beta and tau, and plasma-based biomarkers.Study results will be forthcoming.
Authors
- Óscar López (ORCID: https://orcid.org/0000-0003-2896-6993)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Stewart Anderson (ORCID: https://orcid.org/0000-0001-8948-0650)
- Jinghang Li (ORCID: https://orcid.org/0000-0003-1960-9839)
- Salem Alkhateeb
- Sarah K. Royse (ORCID: https://orcid.org/0000-0003-4846-0180)
- Andrea M. Weinstein (ORCID: https://orcid.org/0000-0001-7932-8049)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Ariel Gildengers (ORCID: https://orcid.org/0000-0001-9216-988X)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Cong Chu
- Brian J. Lopresti
- James E. Emanuel
- Tales Santini (ORCID: https://orcid.org/0000-0003-4533-9190)
- Meryl A. Butters (ORCID: https://orcid.org/0000-0002-2563-817X)
- Andrea Sajewski (ORCID: https://orcid.org/0000-0002-5978-268X)
- Minjie Wu (ORCID: https://orcid.org/0009-0009-8262-7029)
- Tamer S. Ibrahim
- Jihui L. Diaz
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70112
- Citations
- 2
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Science Foundation
- Alzheimer's Association
- University of Pittsburgh
- National Institutes of Health
- Center for Research Computing, University of Pittsburgh
- National Institute on Aging