Phenotypic and genotypic insecticide resistance profiles of main malaria vectors in Kwale county, coastal Kenya
Malaria vectors in Kwale are resistant to pyrethroids. PBO fully restored susceptibility, indicating this resistance could be caused by metabolic mechanism. The presence of kdr and metabolic resistance alleles suggests a recent selection on Anopheles mosquitoes. Pyrethroid-only nets may not fully ensure community protection against malaria in coastal Kenya due to resistance. Operational failure remains uncertain, requiring further studies. Net distribution programs should consider pyrethroid-PBO nets to enhance malaria control effectiveness.
Authors
- Faiz Shee (ORCID: https://orcid.org/0000-0002-1114-6449)
- Brian Bartilol (ORCID: https://orcid.org/0000-0002-8945-0002)
- Carlos Chaccour (ORCID: https://orcid.org/0000-0001-9812-050X)
- Zedekiah Ondieki
- Peter Meli
- Jonathan Karisa (ORCID: https://orcid.org/0000-0002-3383-6782)
- Caroline Wanjiku (ORCID: https://orcid.org/0000-0003-3861-4190)
- Bruno Otieno
- Caroline Kiuru (ORCID: https://orcid.org/0000-0002-0179-5322)
- Tobias Odongo
- Marta F. Maia (ORCID: https://orcid.org/0000-0003-3302-5610)
- Mercy Tuwei
- Miguel Okoko
- Rehema Gona
- Festus Yaa
Institutions
- Pwani University (KE)
- Vector & Vector-Borne Diseases Research Institute (TZ)
- Centro de Investigación Biomédica en Red (ES)
- Barcelona Institute for Global Health (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12936-025-05437-z
- Citations
- 2
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Ministerio de Ciencia e Innovación
- Agencia Estatal de Investigación