Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome
Surrogate markers for plasma NET levels measured in patients with moderate or severe ARDS correlate directly with adverse clinical outcomes and may serve as biomarkers for predicting severe disease. Further studies of surrogate biomarkers for NET formation in moderate-to-severe ARDS are warranted.
Authors
- John L. Rustad (ORCID: https://orcid.org/0000-0001-6166-0414)
- Frederik Denorme (ORCID: https://orcid.org/0000-0003-1442-3568)
- Daniel J. Perry (ORCID: https://orcid.org/0000-0002-0607-2238)
- Elizabeth A. Middleton (ORCID: https://orcid.org/0000-0002-5120-8202)
- Stephanie A. Goldstein (ORCID: https://orcid.org/0000-0002-1236-7964)
- Christian C. Yost (ORCID: https://orcid.org/0000-0002-1258-3595)
- Mark J. Cody
- Samuel Morris Brown (ORCID: https://orcid.org/0000-0003-1206-6261)
- Joni Aoki
- Estelle S. Harris
Institutions
- Washington University in St. Louis (US)
- University of Utah (US)
- Intermountain Medical Center (US)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12950-025-00448-8
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute