Clinical utility and tissue concordance of circulating tumor DNA in pancreatic ductal adenocarcinoma
ctDNA is a promising tool in the detection of somatic variants in pancreas ductal adenocarcinoma. Concordance between ctDNA and tissue is high for patients with untreated metastatic disease, notably for detection of KRAS variants.
Authors
- Alice C. Wei (ORCID: https://orcid.org/0000-0002-2505-959X)
- Darren Cowzer (ORCID: https://orcid.org/0000-0002-0969-3259)
- Kenneth H. Yu (ORCID: https://orcid.org/0000-0002-4774-2672)
- Lily V. Saadat
- Anupriya Singhal (ORCID: https://orcid.org/0000-0001-8816-0065)
- Anna M. Varghese (ORCID: https://orcid.org/0000-0001-5426-0885)
- Wungki Park (ORCID: https://orcid.org/0000-0002-8006-3102)
- Emily Harrold
- Marinela Capanu (ORCID: https://orcid.org/0000-0003-4953-3193)
- Catherine O’Connor (ORCID: https://orcid.org/0000-0003-4080-9149)
- Alice Zervoudakis (ORCID: https://orcid.org/0009-0000-4818-7933)
- Fergus Keane (ORCID: https://orcid.org/0000-0001-6651-2090)
- Anita S. Bowman (ORCID: https://orcid.org/0000-0002-8651-5317)
- Fiyinfolu Balogun (ORCID: https://orcid.org/0000-0003-4703-1560)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Joshua D. Schoenfeld (ORCID: https://orcid.org/0000-0002-3970-9784)
- Fionnuala Crowley (ORCID: https://orcid.org/0000-0001-9101-3912)
- A. Rose Brannon (ORCID: https://orcid.org/0000-0003-4610-0149)
- Michael F. Berger
- Fei Xu (ORCID: https://orcid.org/0000-0001-6325-118X)
- Drew Moss
- Neha Debnath
- Joanne F. Chou
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Cornell University (US)
- St. Vincent's University Hospital (IE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1093/jnci/djaf139
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87