Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
We successfully developed an immunoPET radiotracer targeting toxin B for detection of CDI. Its application in an animal CDI model proved its capacity to detect the source of infection with high specificity, while avoiding confusion with non-specific inflammation.
Authors
- Luís Alcalá
- Alexandra de Francisco (ORCID: https://orcid.org/0000-0002-6113-7233)
- Stina Syvänen (ORCID: https://orcid.org/0000-0002-8196-4041)
- Mario González‐Arjona (ORCID: https://orcid.org/0000-0001-9573-9411)
- Dag Sehlin (ORCID: https://orcid.org/0000-0002-9430-3859)
- Lorena Cussó (ORCID: https://orcid.org/0000-0001-9298-0015)
- Patricia Muñóz (ORCID: https://orcid.org/0000-0001-5706-5583)
- Beatriz Salinas (ORCID: https://orcid.org/0000-0001-9388-5917)
- Manuel Desco (ORCID: https://orcid.org/0000-0003-0989-3231)
- Emilio Bouza (ORCID: https://orcid.org/0000-0001-6967-9267)
- Isabel Gónzalez (ORCID: https://orcid.org/0000-0002-2979-5682)
- María Jesús Fernández‐Aceñero (ORCID: https://orcid.org/0000-0002-2439-3553)
Institutions
- Universidad Complutense de Madrid (ES)
- Uppsala University (SE)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Universidad Carlos III de Madrid (ES)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s41181-025-00350-x
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Ramón Areces
- Comunidad de Madrid
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Ministerio de Ciencia e Innovación
- Centro Nacional de Investigaciones Cardiovasculares
- Instituto de Investigación Sanitaria Gregorio Marañón
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación