A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones
A new synthetic route initiated with Groebke-Blackburn-Bienaymé (GBB) followed by <i>N</i>-acylation, intramolecular Diels-Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is developed. Gaussian computation analysis on the effect of the substitution groups for the IMDA reaction is performed to understand the reaction mechanism.
Authors
- Ashutosh Nath (ORCID: https://orcid.org/0000-0001-8302-0493)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6097-2763)
- John Mark Awad
Institutions
- University of Massachusetts Boston (US)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2025-06-13
- DOI
- https://doi.org/10.3762/bjoc.21.92
- Citations
- 1
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.94