Early Stage Morphogenesis of Transverse Tubules in Rat Cardiomyocytes: The Role of pBIN1
TTs start to develop as budding tubules branching from membrane hubs around Z-discs. This process depends at least partially on the tubulation function of pBIN1 (BIN1 isoforms with PIBM [Bin1+11 and Bin1+11+17]), which is constitutively expressed in rat and human cardiomyocytes. Defective TT morphogenesis due to altered <i>BIN1</i> splicing in cardiomyocytes may have potential implications in heart diseases.
Authors
- Qianjin Guo (ORCID: https://orcid.org/0000-0002-0335-2381)
- Shi‐Qiang Wang (ORCID: https://orcid.org/0000-0001-7784-4461)
- Xian-Jin Xie (ORCID: https://orcid.org/0000-0002-5698-0330)
- Tingting Hou
- Yingna Guo
- Linlin Li (ORCID: https://orcid.org/0000-0003-1041-4533)
- Hongtao Li (ORCID: https://orcid.org/0000-0002-0643-821X)
- Lipeng Wang (ORCID: https://orcid.org/0000-0001-7918-4786)
- Jinghui Liang (ORCID: https://orcid.org/0009-0007-7899-9781)
- Xin-Lei Ma
Institutions
- Florida State University (US)
- Florida A&M University - Florida State University College of Engineering (US)
- Shandong Institute of Automation (CN)
- Institute of Automation (CN)
- L-3 Communications (United States) (US)
- Stanford University (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1161/circresaha.124.325472
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39