Towards a hydrolysis stable artificial base pair with <i>C</i>-glycosides
Artificial base-pairs expand the genetic alphabet and allow for site-specific labeling, for example with fluorophores or spin labels, thereby enhancing the capabilities of biomolecular sensing. We developed CTPT3, a stable <i>C</i>-nucleoside pairing with NaM to form a hydrophobic base pair, and demonstrate its enzymatic incorporation into DNA/RNA and facile modification for labeling.
Authors
- Stephanie Kath‐Schorr (ORCID: https://orcid.org/0000-0002-5180-360X)
- Philip K. Wagner (ORCID: https://orcid.org/0009-0006-3848-1542)
- Robert Dörrenhaus
Institutions
- Institute of Organic Chemistry (PL)
- Institute of Organic Chemistry (HU)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02749g
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00