Literature Review: Immunomodulatory Effect Of Centella Asiatica (L.) Urban Extract

Centella asiatica (L) urban is a plant that has the potential to be a source of immunomodulatory agents because it contains several groups of active compounds, asiaticoside, madecassoside, madecassic acid and asiatic acid, which can act as anti-allergic, anti-inflammatory, and immunomodulators. This study aims to review relevant literature to summarize the immunomodulatory effects produced by Centella asiatica (L.) urban. This study used a literature review design involving 4 experimental study articles published in the last 10 years in the electronic databases PubMed and ScienceDirect. The results of this study showed that C. asiatica has been shown to provide immunomodulatory effects through various mechanisms, including as an anti-inflammatory by decreasing nitrite production, PGE2 and TNF-α, reducing NF-κβ activation, and inhibiting pro-inflammatory mediators induced by IFN-γ and TNF-α, including IL-6 and COX-2. C. asiatica can also act as an antioxidant that inhibits ROS production, stimulates GSH, and binds free radicals. In addition, C. asiatica can also play a role in the adaptive immune response.