Metal‐Free Nitration/Cyclization of Unactivated Olefins to Access Nitroated Tetrahydropyridazines with Sodium Nitrate
A metal‐free radical cascade nitration/cyclization reaction of N ‐homoallylacetohydrazides with sodium nitrite is developed for the synthesis of nitroated tetrahydropyridazines. This protocol features readily available raw material, convenient operation, and good functional group tolerance, providing 36 compounds in acceptable yields.
Authors
- Liqiang Hao
- Yiping Liu (ORCID: https://orcid.org/0009-0001-9196-6593)
- Yafei Ji (ORCID: https://orcid.org/0000-0002-3562-6703)
- Xian Liu (ORCID: https://orcid.org/0000-0001-7540-9634)
- Xiao Yu
- Shengkui Jin
Institutions
- East China University of Science and Technology (CN)
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1002/adsc.202500290
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China