Hyponatremia Presents With Seizure in a Patient With Arnold-Chiari Malformation: A Case Report

Arnold-Chiari malformation (ACM) is a neuroanatomical disorder characterized by the displacement of cerebellar tonsils through the foramen magnum. While traditionally associated with a spectrum of neurological symptoms, hyponatremic seizures remain a rare and underrecognized presentation of ACM. This manuscript explores the potential pathophysiological mechanisms linking ACM to hyponatremia and presents a clinical case illustrating this unusual association. Although seizures are a well-documented manifestation of various neurological conditions, their occurrence secondary to hyponatremia in ACM patients has not been extensively reported in the literature. By examining this rare complication, we aim to enhance clinical awareness and deepen the understanding of the underlying mechanisms that may contribute to this phenomenon.

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Journal
Cureus
Published
2025-06-11
DOI
https://doi.org/10.7759/cureus.85819
Primary Topic
Electrolyte and hormonal disorders
Type
article
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0.00
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article

Hyponatremia Presents With Seizure in a Patient With Arnold-Chiari Malformation: A Case Report

Mohamed Zuhail K Peediyakkal, Bara M Al-Qudah, Sunil Hassan Koya, Abdulqadir J. J. Nashwan et al.
Cureus
Electrolyte and hormonal disorders
article

Hyponatremia Presents With Seizure in a Patient With Arnold-Chiari Malformation: A Case Report

Mohamed Zuhail K Peediyakkal, Bara M Al-Qudah, Sunil Hassan Koya, Abdulqadir J. J. Nashwan, Nevin Kannappilly, Humam Rajha, Nabil Sherif Mahmood, Ashib Thurakkal, Saifil Sidhique
article en

Abstract

Arnold-Chiari malformation (ACM) is a neuroanatomical disorder characterized by the displacement of cerebellar tonsils through the foramen magnum. While traditionally associated with a spectrum of neurological symptoms, hyponatremic seizures remain a rare and underrecognized presentation of ACM. This manuscript explores the potential pathophysiological mechanisms linking ACM to hyponatremia and presents a clinical case illustrating this unusual association. Although seizures are a well-documented manifestation of various neurological conditions, their occurrence secondary to hyponatremia in ACM patients has not been extensively reported in the literature. By examining this rare complication, we aim to enhance clinical awareness and deepen the understanding of the underlying mechanisms that may contribute to this phenomenon.

CureusVol. 17(6)
Hamad Medical Corporation (QA), Qatar University (QA)
Openalex Percentile: Top 78%
Electrolyte and hormonal disorders
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Hyponatremia Presents With Seizure in a Patient With Arnold-Chiari Malformation: A Case Report — Mohamed Zuhail K Peediyakkal, Bara M Al-Qudah, et al. · Cureus (2025) | TGRS Research Map | TGRS