A microfluidic platform for studying supercritical fluid crystallization and its applications
We demonstrate here the development and use of an on-chip crystallization microfluidic device combined with <i>in situ</i> analytical techniques for supercritical antisolvent crystallization. The setup facilitated real-time observation of crystallization events under pressure, giving critical insights into the time-dependent dynamics of the crystallization process. By integrating Raman spectroscopy for continuous monitoring, the system enabled precise control of local species concentrations during diffusion-driven crystallization. The microfluidic platform demonstrated effectiveness in rapid crystal screening and the identification of new co-crystals.
Authors
- Pascale Subra‐Paternault (ORCID: https://orcid.org/0000-0003-2882-2180)
- Samuel Marre (ORCID: https://orcid.org/0000-0001-8889-187X)
- Fatma Ercicek
- Christelle Harscoat‐Schiavo (ORCID: https://orcid.org/0000-0001-8798-2825)
- Olivier Nguyen (ORCID: https://orcid.org/0000-0002-2484-7113)
- Arnaud Erriguible (ORCID: https://orcid.org/0000-0003-2454-5307)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Institut de Chimie de la Matière Condensée de Bordeaux (FR)
- Chimie et Biologie des Membranes et des Nanoobjects (FR)
- Institut Polytechnique de Bordeaux (FR)
Publication Details
- Journal
- Lab on a Chip
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4lc01032a
- Primary Topic
- Phase Equilibria and Thermodynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche