Effects of Transcranial Ultrasound Stimulation on Upper Limb Motor Function and Emotional State in Patients with Post-Stroke Depression

目的：通过低强度经颅超声刺激是否可以改善卒中后抑郁，探究其可能机制并以期为卒中后抑郁患者进一步治疗提供新的康复策略。方法：选取卒中后抑郁患者30例为研究对象，按照计算机随机分组分为假刺激对照组和联合治疗组，每组15例，干预组进行LITUS、常规药物和康复治疗，对照组除外常规药物及康复治疗，经颅超声刺激为假刺激治疗。结果：两组在治疗前Wolf运动功能测试量表、PHQ-9、BI指数无显著差异(p > 0.05)，在治疗后两组评估指标均较治疗前有所改善(p Objective: This study aims to determine whether low-intensity transcranial ultrasound stimulation (LITUS) can improve post-stroke depression (PSD), explore its potential mechanisms, and provide a novel rehabilitation strategy for further treatment of PSD patients. Methods: Thirty patients with post-stroke depression were selected and randomly divided into a sham stimulation control group and a combined treatment group, with 15 patients in each group. The intervention group received LITUS in combination with conventional pharmacological and rehabilitation treatments. The control group received only conventional pharmacological and rehabilitation treatments along with sham ultrasound stimulation. Results: There were no significant differences between the two groups in the Wolf Motor Function Test, Patient Health Questionnaire-9 (PHQ-9), and Barthel Index (BI) before treatment (p > 0.05). After treatment, all evaluation indicators improved in both groups compared to baseline (p < 0.05). However, the degree of improvement in the intervention group was significantly greater than that in the control group (p < 0.05). Conclusion: LITUS shows therapeutic efficacy in the treatment of post-stroke depression and effectively improves various functional outcomes in PSD patients.