Nigericin-induced apoptosis in acute myeloid leukemia via mitochondrial dysfunction and oxidative stress
Nigericin induces apoptosis in AML cells by disrupting mitochondrial function and enhancing oxidative stress. Its nanomolar potency highlights the need for further mechanistic studies and <i>in vivo</i> evaluations to explore its potential in AML treatment.
Authors
- Syed G. Dastager (ORCID: https://orcid.org/0000-0002-8316-1242)
- Nitika Tripathi (ORCID: https://orcid.org/0000-0002-2154-5881)
- P. Gopinath (ORCID: https://orcid.org/0000-0003-1379-1203)
- Ashish Kumar Jha (ORCID: https://orcid.org/0000-0001-5998-3206)
- Banu Arun
- Syed Kazim Hasan
Institutions
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
- National Chemical Laboratory (IN)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.062951
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00