Synthesis and Antimicrobial Activity of Novel 2,6-diundecylidenecyclohexan-1-one Derivatives

Twelve newly prepared compounds starting from cycloheanone are done. Cyclohexanone reacts with undecanal to afford 2,6-diundecylidenecyclohexan-1-one 1. 2,6-Diundecylidenecyclohexan-1-one 1 reacts with urea, and thiourea to afford quinazoline derivatives 2a,b. Cyclohexanone derivative 1 reacts with guanidine, and aminoguanidine to form quinazoline derivatives 3a,b. Compound 1 reacts with semicarbazide, and thiosemicarbazide to give indazole derivatives 4a,b. Also, cyclohexanone derivative 1 reacts with carbon disulfide to afford benzo[b]thiophene derivative 5. Cyclohexanone derivative 1 reacts with hydrazine hydrate, and hydroxylamine to form indazole derivatives 6a,b. Quinazoline derivative 3b reacts with p-chlorobenzaldehyde to afford octahydroquinazoline derivative 7. Also, quinazoline derivative 3b reacts with ribose, and glucose to afford sugar derivatives 8a,b. Antimicrobial screening of new prepared compounds was done against G+ve bacteria, G-ve bacteria, and two fungi. Several compounds show promising antimicrobial activity as compared with reference drug used.