Scaffolds for Tissue Engineering: Keys of success

Aim: the aim of this article is to comprehensively review the key factors responsible for scaffold success. Starting from the different materials used, and their importance. To the factors related to manufacture and strength. Materials and Methods: An electronic search for systematic review was conducted in PubMed/MEDLINE [www.ncbi.nlm.nih.gov], Cochrane [www.cochrane.org], Scopus [www.scopus.com] databases, and dental journals related to endodontics, Oral biology, Dental biomaterials and pediatric dentistry to identify the research investigations associated with scaffold fabrication, types, relation between mechanical properties and biocompatibility, and rates of biodegradability. A sample of relevant studies were identified in our search of 100 using simple random sampling. Results: Balance between mechanical properties, biocompatibility and biodegradability should be considered in order to reach the highest levels of success, as scaffold is one of the success keys in tissue engineering. Conclusions: An ideal scaffold must fulfill critical requirements, including; biocompatibility, biodegradability, mechanical strength, appropriate porosity for nutrient and oxygen diffusion, incorporation of bioactive molecules, and use of advanced fabrication methods such as 3D printing can enhance scaffold performance and ensure scaffolds effectively support tissue regeneration.