Formulation and Evaluation of Transdermal Patches Containing Metformin for the Management of Gestational Diabetes

Transdermal drug delivery systems offer several benefits because drugs administered are able to bypass hepatic first-pass metabolism and factors that alter pharmacokinetics in the gastrointestinal tract. Considering all problems associated with oral administration of anti-diabetic drug, attempt has been made to develop TDDS in order to achieve a better release pattern. Therefore, the present study involves the development of an anti-diabetic drug (metformin hydrochloride) in transdermal drug delivery form and their evaluation.