Silver(I) Complexes Based on 2-Quinoline or 2-Quinoxaline Derivatives of Amino Acid Esters as New Antiviral Drugs

Here, we prepared a number of quinoline-2-carboxylic acid or quinoxaline-2-carboxylic acid amino acid esters derivatives with aromatic and aliphatic terminal groups (Qln-Ser-OMe, Qln-Thr-OMe, Qox-Thr-OMe, and Qox-Trp-OMe). Compounds were characterized by IR, NMR spectroscopies and MS spectrometry. Silver(I) complexes with the organic ligands of the general form [AgL2]NO3 were prepared in order to increase their water solubility. The structures of compounds Qox-Trp-OMe and [AgL2]NO3 (L = Qln-Ser-OMe) were determined by single-crystal X-ray diffraction. The proposed compounds in the form of water-soluble silver(I) nitrate complexes were found to be effective in suppressing the reproduction of the rimantadine-resistant influenza virus strain A/IIV-Orenburg/83/2012(H1N1)pdm09 in experiments in vitro using a MDCK cell culture model.