Dendritic cell dysfunction, including impaired IL-12 production, is associated with chronic pulmonary aspergillosis
Our findings suggest that immune dysfunction in CPA involves DC and monocyte impairments, potentially contributing to IFNγ deficiency through reduced IL-12 production and co-stimulatory capacity in cDC1s. These results also hint at the presence of innate immune memory in CPA patients with prior TB. Our study advances understanding of the immune dysfunction underlying CPA.
Authors
- Robert Lord (ORCID: https://orcid.org/0000-0001-9008-2502)
- Andrew S. MacDonald (ORCID: https://orcid.org/0000-0002-5356-1149)
- Mathilde Chamula (ORCID: https://orcid.org/0000-0001-7290-2562)
- Sara Gago (ORCID: https://orcid.org/0000-0002-7027-4598)
- Chris Kosmidis (ORCID: https://orcid.org/0000-0003-0662-1265)
- Stefano A. P. Colombo (ORCID: https://orcid.org/0000-0002-3346-3437)
Institutions
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Institute of Immunology (HR)
Publication Details
- Journal
- Clinical & Experimental Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/cei/uxaf038
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00