Genetic Polymorphisms of Apolipoprotein E and Their Impact on Ischemic Stroke Severity and Recovery

ABSTRACT Stroke remains a leading cause of mortality and disability, presenting a substantial public health challenge. In China, millions of individuals are affected by stroke, with an increasing prevalence among younger populations, exacerbating socioeconomic burdens. Ischemic stroke (IS), accounting for over 80% of all stroke cases, is primarily caused by cerebral artery occlusion, leading to brain tissue ischemia and subsequent neurological deficits. Apolipoprotein E (APOE), a key regulator of lipid metabolism and vascular function, plays a critical role in IS pathogenesis and recovery. Recent studies have highlighted the influence of APOE genetic polymorphisms on stroke incidence, severity, functional recovery, and associated cognitive dysfunction. Additionally, animal models provide insights into the molecular mechanisms of APOE in ischemic brain injury and repair. This review summarizes the latest findings on the role of APOE in IS, encompassing its impact on stroke prevalence, recovery, cognitive outcomes, and related conditions. These insights may offer valuable perspectives for identifying risk factors and developing targeted therapeutic strategies for IS.