CTRP7 as a molecular biomarker associating with responsiveness to pulmonary vasodilators: insights from human and animal studies in pulmonary arterial hypertension
In patients with PAH, RNA sequencing of PASMCs revealed elevated expression of CTRP7 among candidate biomarkers. Patients with PAH had higher plasma CTRP7 levels than those without PH. Mechanistically, CTRP7 regulated PTGIR internalization via the IL-6-Rab5a axis, influencing responsiveness to selexipag. Herein, CTRP7 emerged as a crucial biomarker associating with responsiveness to prostacyclin analogues, advancing the development of PAH treatment strategies.
Authors
- Taijyu Satoh (ORCID: https://orcid.org/0000-0002-1795-6872)
- Haruka Sato (ORCID: https://orcid.org/0000-0001-6839-0146)
- Naoki Chiba (ORCID: https://orcid.org/0009-0003-0296-9026)
- Satoshi Yasuda (ORCID: https://orcid.org/0000-0002-7470-5236)
- Satoshi Miyata (ORCID: https://orcid.org/0000-0003-2400-7525)
- Kotaro Nochioka (ORCID: https://orcid.org/0000-0001-8297-8624)
- Shigeo Godo (ORCID: https://orcid.org/0000-0002-4985-7828)
- Kaito Yamada (ORCID: https://orcid.org/0000-0002-1556-607X)
- Yoshinori Okada (ORCID: https://orcid.org/0000-0001-7739-7657)
- Yusuke Yamada (ORCID: https://orcid.org/0000-0003-2684-516X)
- Takashi Nakata
- Hisashi Oishi (ORCID: https://orcid.org/0000-0002-1381-6362)
- Saori Yamamoto
- Kohei Komaru
- Sho Onuma
- Nobuhiro Yaoita
Institutions
- Tohoku University (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1093/cvr/cvaf064
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Japan Agency for Medical Research and Development