Targeting the Liver Serine Protease <scp>TMPRSS6</scp> Ameliorates Steatosis and Attenuates Fibrosis in Experimental <scp>MASLD</scp>

Our findings reveal a novel functional crosstalk between TMPRSS6 and PPARα. Pharmacological downregulation of Tmprss6 in experimental MASLD mitigates hepatosteatosis, inflammation and fibrosis by enhancing PPARα signalling and attenuating ferroptosis.

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Publication Details

Journal
Liver International
Published
2025-06-11
DOI
https://doi.org/10.1111/liv.70163
Citations
4
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
5.42

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article

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD

Valeria Mannella, Giovanna Musco, Francesca Carlomagno, Shuling Guo et al.
4 citations
Liver International
Liver Disease Diagnosis and Treatment
5.42
article

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD

Valeria Mannella, Giovanna Musco, Francesca Carlomagno, Shuling Guo, Letizia Bavuso Volpe, Enrica Gilberti, Alessandro Cherubini, Giorgia Federico, Valeria Furiosi, Luca Valenti, Alessia Pagani, Mariateresa Pettinato, Giuseppe De Palma, Sandro Altamura, Laura Silvestri, Antonella Nai, Serena Pelusi, Rossana Carleo, Anxhela Dano
article en
4 citations

Abstract

Our findings reveal a novel functional crosstalk between TMPRSS6 and PPARα. Pharmacological downregulation of Tmprss6 in experimental MASLD mitigates hepatosteatosis, inflammation and fibrosis by enhancing PPARα signalling and attenuating ferroptosis.

Liver InternationalVol. 45(7)
Vita-Salute San Raffaele University (IT), University of Milan (IT), Heidelberg University (DE), Ionis Pharmaceuticals (United States) (US), University Hospital Heidelberg (DE), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), IRCCS Ospedale San Raffaele (IT), University of Naples Federico II (IT), University of Brescia (IT)
Gilead Sciences, Fondazione Cariplo, Ministero della Salute, Ministero dell'Università e della Ricerca
Good health and well-being
Openalex Percentile: Top 4%
Liver Disease Diagnosis and Treatment
5.42
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