Targeting the Liver Serine Protease <scp>TMPRSS6</scp> Ameliorates Steatosis and Attenuates Fibrosis in Experimental <scp>MASLD</scp>
Our findings reveal a novel functional crosstalk between TMPRSS6 and PPARα. Pharmacological downregulation of Tmprss6 in experimental MASLD mitigates hepatosteatosis, inflammation and fibrosis by enhancing PPARα signalling and attenuating ferroptosis.
Authors
- Valeria Mannella
- Giovanna Musco (ORCID: https://orcid.org/0000-0002-0469-2994)
- Francesca Carlomagno (ORCID: https://orcid.org/0000-0002-1483-4677)
- Shuling Guo (ORCID: https://orcid.org/0000-0001-6703-9303)
- Letizia Bavuso Volpe
- Enrica Gilberti
- Alessandro Cherubini (ORCID: https://orcid.org/0000-0003-4756-2046)
- Giorgia Federico (ORCID: https://orcid.org/0000-0001-9420-6699)
- Valeria Furiosi
- Luca Valenti (ORCID: https://orcid.org/0000-0001-8909-0345)
- Alessia Pagani (ORCID: https://orcid.org/0000-0003-2374-4988)
- Mariateresa Pettinato (ORCID: https://orcid.org/0000-0002-3259-4865)
- Giuseppe De Palma (ORCID: https://orcid.org/0000-0001-9821-3060)
- Sandro Altamura (ORCID: https://orcid.org/0000-0002-6781-1073)
- Laura Silvestri (ORCID: https://orcid.org/0000-0002-8726-9808)
- Antonella Nai (ORCID: https://orcid.org/0000-0002-0739-5282)
- Serena Pelusi
- Rossana Carleo
- Anxhela Dano
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Heidelberg University (DE)
- Ionis Pharmaceuticals (United States) (US)
- University Hospital Heidelberg (DE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- IRCCS Ospedale San Raffaele (IT)
- University of Naples Federico II (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Liver International
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1111/liv.70163
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Gilead Sciences
- Fondazione Cariplo
- Ministero della Salute
- Ministero dell'Università e della Ricerca